羧甲基壳聚糖在口腔组织工程中的应用

编辑：中国组织工程研究时间：2022-11-24 点击：

School of Stomatology • Stomatology Hospital of Shanxi Medical University, Shanxi Provincial Key Laboratory of Oral Disease Prevention and New Materials, Taiyuan 030000, Shanxi Province, China

Received:2021-12-02 Accepted:2022-01-13 Online:2023-01-28 Published:2022-06-01
Contact: Wu Xiuping, MD, Chief physician, Professor, Doctoral supervisor, School of Stomatology • Stomatology Hospital of Shanxi Medical University, Shanxi Provincial Key Laboratory of Oral Disease Prevention and New Materials, Taiyuan 030000, Shanxi Province, China
About author:Zong Mingrui, Master candidate, School of Stomatology • Stomatology Hospital of Shanxi Medical University, Shanxi Provincial Key Laboratory of Oral Disease Prevention and New Materials, Taiyuan 030000, Shanxi Province, China
Supported by:
Science and Technology Innovation Project for Colleges and Universities of Shanxi Province, No. 2020L0212 (to LHY); Research Fund Project for Returned Overseas Students of Shanxi Province, No. HGKY2019-055 (to LB)

摘要：

文题释义：
羧甲基壳聚糖：羧基化的一种壳聚糖，主要有3种形式：N，O-羧甲基壳聚糖、N，N-羧甲基壳聚糖、O-羧甲基壳聚糖。
组织再生：寻找有效的生物材料，促进机体自我修复与再生或构建出新的组织与器官，以改善或恢复损伤组织和器官的功能。

背景：作为天然生物材料壳聚糖的一种衍生物，羧甲基壳聚糖具有独特的水溶性、成膜性、缓释性，在组织工程领域具有广阔的应用前景。
目的：综述羧甲基壳聚糖相较于壳聚糖的优势以及在口腔组织再生方面的应用。
方法：利用计算机检索PubMed、中国知网数据库相关文献，中文检索词“羧甲基壳聚糖 AND 组织工程，羧甲基壳聚糖 AND 口腔医学”，英文检索词“carboxymethyl chitosan AND tissue engineering，carboxymethyl chitosan AND (dentistry OR stomatology)”，检索时限为2006年1月至2021年10月，通过阅读和分析文献进行初步筛选，以排除重复文献和低相关性文献，最终纳入文献51篇进行结果分析。
结果与结论：羧甲基壳聚糖作为一种具有良好生物相容性、可降解的无毒材料，在骨组织再生、牙体组织再生、牙周组织再生方面已取得理想的进展。羧甲基壳聚糖相比壳聚糖具有更好的水溶性、成膜性和离子结合性，这极大扩展了其在口腔组织工程的应用。羧甲基壳聚糖单独使用可发挥抗菌效果，促细胞增殖、分化，或是作为支架材料、水凝胶、改性材料与生物活性成分和生长因子联合使用均达到了预期的实验效果。

https://orcid.org/0000-0003-1634-3756 (宗明锐)

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: 羧甲基壳聚糖, 壳聚糖衍生物, 组织工程, 口腔组织构建, 牙周再生, 再矿化, 骨再生

Abstract: BACKGROUND: As a derivative of natural biological material chitosan, carboxymethyl chitosan has a wide application prospect in tissue engineering due to its unique water-solubility, film-forming and sustained-release properties.
OBJECTIVE: To review the advantages of carboxymethyl chitosan compared with chitosan and its application in oral tissue regeneration.
METHODS: PubMed and CNKI were searched using the key words of “carboxymethyl chitosan AND Tissue engineering, carboxymethyl chitosan AND (dentistry OR stomatology)” for articles published from January 2006 to October 2021. Preliminary screening was conducted through reading and analysis to exclude duplicate articles and low-correlation articles. Eventually, 51 articles were included for result analysis.
RESULTS AND CONCLUSION: Carboxymethyl chitosan, as a non-toxic material with valuable biocompatibility and biodegradation, has made ideal progresses in bone tissue regeneration, tooth tissue regeneration and periodontal tissue regeneration. Carboxymethyl chitosan has better water solubility, membrane formation and ion binding properties than chitosan, which greatly expands its application in oral tissue engineering. Carboxymethyl chitosan has achieved the expected experimental results whether it is used alone to exert antibacterial effect and promote cell proliferation and differentiation, or used as a scaffold material, hydrogel, modified material and biological active ingredients and growth factors.

Key words: carboxymethyl chitosan, chitosan derivatives, tissue engineering, oral tissue construction, periodontal regeneration, remineralization, bone regeneration

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